tldr Area Under the Curve (AUC) of Receiver Operating Characteristic (ROC) is a terrible metric for a genomics problem. Do not use it. This metric also goes by AUC or AUROC. Use Precision Recall AUC.
Inspiration for this post I am working on a machine learning problem in genomics I was getting really confused why AUROC was so worthless scienceTwitter featuring Anshul Kundaje I want to save you (some time) What’s a ROC?